pharmacokinetic相关论文
Dahuang-Gancao decoction (DGD) is a classical formula,which is commonly used for reliving constipation in Chinese clinic......
Pharmacokinetics of oxytetracycline in yellow catfish (Pelteobagrus fulbvidraco) with a single and m
A pharmacokinetic study of oxytetracycline (OTC) following a single (100 mg/kg) or a multi-dose (100 mg/kg for 5 days) o......
Clinicalevaluationofameropenemdosagestrategybasedonapopuolationpharmacokinetic-pharmacody
目的 Lowerrespiratorytractinfection(LRTI),ishighlyprevalentintheelderlypopulation.Meropenemisusuallyusedinthetreatmentof......
DETERMINATION OF LEHMANNINE IN RAT PLASMA BY HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY AND ITS APPLICAT
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Pharmacokinetic parameters of losartan and losartan/hydrochlorothiazide tablets in healthy chinese m
OBJECTIVE To evaluate and compare the of Losartan and Losartan/Hydrochlorothiaside combination tablets in healthy chinse......
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3D-QSAR-aided design, synthesis, in vitro and in vivo evaluation of dipeptidyl boronic acid proteaso
Proteasome had been clinically validated as an effective target for the treatment of cancers.The high selectivity and lo......
Objective To prepare arsenic trioxide-loaded pH-responsive mesoporous silica nanoparticles (PAA-ATO-MSNs) and investigat......
Curcumae Rhizoma (CR) has been used in traditional Chinese medicine for thousands of years as an anti-blood stasis and p......
Renshen-Shouwu Capsule (RSSW) is a patented Traditional Chinese Medicine,that has been widely used to treat neural disor......
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A rapid and sensitive ultra performance liquid chromatography-tandem mass spectrometry method was developed for simultan......
Pharmacokinetics in rats and in vitro Species difference in hydrolysis of a novel nitric dioxide don
ZJM-289, a novel nitric oxide-donating derivative of 3-n-butylphthalide, has been reported to alleviate cerebral ischemi......
Effects of Rifampin on the pharmacokinetics of Salvianolic acid A, mediated by organic anion-transpo
This study aimed to examine the effects of Rifampin (RIF) on the pharmacokinetics of Salvianolic acid A (SAA) in rats.Co......
Pharmacokinetic Analyses of Paclitaxel in East-Asian Patients with Nasopharyngeal Carcinoma,a prospe
Purpose:Times above certain Paclitaxel(PTX)concentrations(Tcon)exceeding a particular threshold has been clearly shown t......
Pharmacokinetic/Pharmacodynamic Modeling: Effect of Ibutilide on the QTcF Interval in Healthy Male S
Background: Ibutilide, a class Ⅲ antiarrhythmic agent, is primarily used for conversion of atrial flutter and fibrillat......
Simultaneous determination of glimepiride and pioglitazone in human plasma by liquid chromatography-
The rapid,sensitive,and selective liquid chromatography–electrospray ionization–tandem mass spectrometry method (LC–E......
Objective: To develop a sensitive, specific and accurate ultra performance liquid chromatography-electronic spray ion-ma......
Pharmacokinetic behavior of argirein,a super molecule derived from rhein,is characterized as slow re
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A highly sensitive and rapid liquid chromatography-tandem mass spectrometry method was developed for the determination o......
A sensitive,simple and rapid ultra fast liquid chromatography (UFLC)-ESI-MS/MS method was established for the simultaneo......
Synthesis of liguzinediol acetyl amino acid ester prodrugs and their biological evaluation as promis
The liguzinediol was a potential drug for the treatment of heart failure with high effect and low safety risk.However,in......
Probucol(PB)which was an insoluble drug,was widely used totreat hyperlipidemia and atherosclerosis.The solid dispersions......
a cell-culture microfluidic platform with controllable valves for SERS-based pharmacokinetic analysi
In medical fields,pharmacokinetic detection and synergistic effects of multiple drugs have cost researches lots of time ......
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Pharmacokinetic and Pharmacodynamic Efficacies of Continuous versus Intermittent Administration of M
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In vitro permeability of round window membrane to transforming dexamethasone with delivery vehicles-
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Sesquiterpene lactones of Aucklandia lappa: Pharmacology,pharmacokinetics, toxicity, and structure–a
The medicinal part of Aucklandia lappa(Asteraceae) is its dried root,which is one of the commonly used Chinese medicinal......
Objective.The objectives of the present study were to assess pharmacokinetics,preliminary pharmacodynamics,and safet......
Lapatinib promotes the incidence of hepatotoxicity by increasing chemotherapeutic agent accumulation
Background Lapatinib has been used in combination with capecitabine or paclitaxeltotreatpatients with progressive HE......
目的 考察葛根素及葛根提取物在大鼠体内的药代动力学差异.方法 大鼠分别灌胃给予葛根素(500 mg/kg)或葛根提取物(相当于葛根素500......
The pharmacokinetics of milbemycin oxime was investigated in dogs following oral (per os, PO) and intravenous (IV) admin......
目的：研究中国健康男性受试者CYP2C19遗传多态性对西酞普兰体内代谢的影响。方法24名中国健康男性受试者空腹单次口服西酞普兰片20 ......
目的 评价盐酸安妥沙星片在中国健康受试者空腹和餐后单次给药的药代动力学.方法 按随机、开放、单剂量(200,400,600 mg)空腹和餐......
目的评价多黏菌素E甲磺酸钠（CMS）对感染泛耐药鲍曼不动杆菌（PDR-AB）或泛耐药铜绿假单胞菌（PDR-PA）重症患者的有效性及安全性。方法筛选安......
目的建立离子交换色谱法人血浆和尿液中盐酸二甲双胍浓度的测定方法,并应用于人体药代动力学研究。方法血浆样本采用加入含有内标(......
目的 研究甲磺酸帕珠沙星片在中国健康受试者多次给药的药动学.方法 12名健康受试者男女各半,口服甲磺酸帕珠沙星片,每天2次,每次5......
The present study was aimed at the comparison of the pharmacokinetics of pure chlorogenic acid and extract of Solanum ly......
Pharmacokinetics, Biodistribution and Elimination of Recombinant Human Homoserine Thymosin in Rats a
Objective:To study the pharmacokinetic,distribution and elimination properties of rhT α 1 after intravenous (i.v.) and ......
Sesquiterpene lactones of Aucklandia lappa:Pharmacology,pharmacokinetics,toxicity,and structure-acti
The medicinal part ofAucklandia lappa (Asteraceae) is its dried root,which is one of the commonly used Chinese medicinal......
目的制备干扰素α-2b(IFNα-2b)干粉吸入剂,并评价其体外性质以及大鼠体内的药动学性质。方法冷冻干燥并研磨后制备IFNα-2b干粉吸......
目的研究健康志愿者服用刺葡萄籽油后对匹伐他汀药动学的影响。方法用自身前后对照随机交叉的试验方法,筛选8名健康受试者,男女各......
目的系统评价五酯胶囊(片)对他克莫司(FK506)血药浓度及药动学参数的影响。方法检索PubMed、中国生物医学文献数据库、中国知网、......
目的建立血浆中阿仑膦酸钠的HPLC-FLD检测方法,并应用于药动学研究。方法采用Kromasil-C18柱(4.6 mm×150 mm,5μm);流动相:甲醇-......
目的：考察温控型胰岛素液体肛门栓在四氧嘧啶致糖尿病兔体内的药动学。方法36只糖尿病兔随机分成6组，对照组分别给生理氯化钠溶液和......
茴香酸对羟基苯乙酯(HPA)是中药羌活和宽叶羌活的主要生物活性成分之一.本文建立了一种快速、特异的反相高效液相色谱法(RP-HPLC)......
对乙酰氨基酚琥珀酸酯(AP-S)进入动物机体后能很快分解成对乙酰氨基酚(APAP).为探明对乙酰氨基酚琥珀酸酯在家兔体内的动力学特征,......
建立一种简便、高灵敏度的液相串联质谱分析方法测定人血浆中妥洛特罗的浓度.以异丙醇-正己烷(5∶95,v/v)为提取试剂,妥洛特罗-d9......
赤芍总苷是从赤芍中得到的有效部位,它具有许多的生物学活性.然而,由于其溶解性差,生物利用度也非常低,使其应用受到限制.本研究将......
